H2N2V1, France, Analysis, bibRecord, 000184

Genetic Structure of Human A/H1N1 and A/H3N2 Influenza Virus on Corsica Island: Phylogenetic Analysis and Vaccine Strain Match, 2006-2010.

Identifieur interne : 000184 ( France/Analysis ); précédent : 000183; suivant : 000185

Genetic Structure of Human A/H1N1 and A/H3N2 Influenza Virus on Corsica Island: Phylogenetic Analysis and Vaccine Strain Match, 2006-2010.

Auteurs : Alessandra Falchi [France] ; Jean Pierre Amoros [France] ; Christophe Arena [France] ; Jean Arrighi [France] ; François Casabianca ; Laurent Andreoletti [France] ; Clément Turbelin [France] ; Antoine Flahault [France] ; Thierry Blanchon [France] ; Thomas Hanslik [France] ; Laurent Varesi [France]

Source :

PLoS ONE [ 1932-6203 ] ; 2011.

RBID : Hal:hal-00628437

Abstract

BACKGROUND: The aim of this study was to analyse the genetic patterns of Hemagglutinin (HA) genes of influenza A strains circulating on Corsica Island during the 2006-2009 epidemic seasons and the 2009-2010 pandemic season. METHODS: Nasopharyngeal samples from 371 patients with influenza-like illness (ILI) were collected by General Practitioners (GPs) of the Sentinelles Network through a randomised selection routine. RESULTS: Phylogenetic analysis of HA revealed that A/H3N2 strains circulating on Corsica were closely related to the WHO recommended vaccine strains in each analyzed season (2006-2007 to 2008-2009). Seasonal Corsican influenza A/H1N1 isolated during the 2007-2008 season had drifted towards the A/Brisbane/59/2007 lineage, the A/H1N1 vaccine strain for the 2008-2009 season. The A/H1N1 2009 (A/H1N1pdm) strains isolated on Corsica Island were characterized by the S220T mutation specific to clade 7 isolates. It should be noted that Corsican isolates formed a separate sub-clade of clade 7 as a consequence of the presence of the fixed substitution D222E. The percentages of the perfect match vaccine efficacy, estimated by using the p(epitope) model, against influenza viruses circulating on Corsica Island varied substantially across the four seasons analyzed, and tend to be highest for A/H1N1 compared with A/H3N2 vaccines, suggesting that cross-immunity seems to be stronger for the H1 HA gene. CONCLUSION: The molecular analysis of the HA gene of influenza viruses that circulated on Corsica Island between 2006-2010 showed for each season the presence of a dominant lineage characterized by at least one fixed mutation. The A/H3N2 and A/H1N1pdm isolates were characterized by multiples fixation at antigenic sites. The fixation of specific mutations at each outbreak could be explained by the combination of a neutral phenomenon and a founder effect, favoring the presence of a dominant lineage in a closed environment such as Corsica Island.

Url:

https://hal.archives-ouvertes.fr/hal-00628437

DOI: 10.1371/journal.pone.0024471

Affiliations:

France

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000112
to stream Hal, to step Curation: 000112
to stream Hal, to step Checkpoint: 000245
to stream Main, to step Merge: 000B90
to stream Main, to step Curation: 000B87
to stream Main, to step Exploration: 000B87
to stream France, to step Extraction: 000184

Links to Exploration step

Hal:hal-00628437

Le document en format XML

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<author><name sortKey="Amoros, Jean Pierre" sort="Amoros, Jean Pierre" uniqKey="Amoros J" first="Jean Pierre" last="Amoros">Jean Pierre Amoros</name>
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</author>
<author><name sortKey="Arrighi, Jean" sort="Arrighi, Jean" uniqKey="Arrighi J" first="Jean" last="Arrighi">Jean Arrighi</name>
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<country>France</country>
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</author>
<author><name sortKey="Casabianca, Francois" sort="Casabianca, Francois" uniqKey="Casabianca F" first="François" last="Casabianca">François Casabianca</name>
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<author><name sortKey="Andreoletti, Laurent" sort="Andreoletti, Laurent" uniqKey="Andreoletti L" first="Laurent" last="Andreoletti">Laurent Andreoletti</name>
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<country>France</country>
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</author>
<author><name sortKey="Turbelin, Clement" sort="Turbelin, Clement" uniqKey="Turbelin C" first="Clément" last="Turbelin">Clément Turbelin</name>
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          <orgName type="acronym">ESIM</orgName>
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<country>France</country>
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</author>
<author><name sortKey="Flahault, Antoine" sort="Flahault, Antoine" uniqKey="Flahault A" first="Antoine" last="Flahault">Antoine Flahault</name>
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          <orgName type="acronym">ESIM</orgName>
          <desc>            <address>              <addrLine>Faculte de Médecine Saint-Antoine 27, Rue Chaligny 75571 Paris Cedex 12</addrLine>
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<country>France</country>
</affiliation>
</author>
<author><name sortKey="Blanchon, Thierry" sort="Blanchon, Thierry" uniqKey="Blanchon T" first="Thierry" last="Blanchon">Thierry Blanchon</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-3065" status="OLD">          <orgName>Epidémiologie des maladies infectieuses et modélisation</orgName>
          <orgName type="acronym">ESIM</orgName>
          <desc>            <address>              <addrLine>Faculte de Médecine Saint-Antoine 27, Rue Chaligny 75571 Paris Cedex 12</addrLine>
              <country key="FR"></country>
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          <orgName type="acronym">UPMC</orgName>
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<country>France</country>
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<author><name sortKey="Hanslik, Thomas" sort="Hanslik, Thomas" uniqKey="Hanslik T" first="Thomas" last="Hanslik">Thomas Hanslik</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-3065" status="OLD">          <orgName>Epidémiologie des maladies infectieuses et modélisation</orgName>
          <orgName type="acronym">ESIM</orgName>
          <desc>            <address>              <addrLine>Faculte de Médecine Saint-Antoine 27, Rue Chaligny 75571 Paris Cedex 12</addrLine>
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          <orgName type="acronym">UPMC</orgName>
          <date type="end">2017-12-31</date>
          <desc>            <address>              <addrLine>4 place Jussieu - 75005 Paris</addrLine>
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</tutelle>
<tutelle name="U707" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">          <idno type="IdRef">026388278</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
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</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Varesi, Laurent" sort="Varesi, Laurent" uniqKey="Varesi L" first="Laurent" last="Varesi">Laurent Varesi</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-843" status="VALID">          <orgName>Sciences pour l'environnement</orgName>
          <orgName type="acronym">SPE</orgName>
          <desc>            <address>              <addrLine>Adresse 1 (principale): Campus GRIMALDI, Bâtiment PPDB, 20250 Corte Adresse 2: Lieu dit Vignola, route des sanguinaires, 20000 Ajaccio</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://spe.univ-corse.fr</ref>
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          <orgName type="acronym">UPP</orgName>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">https://www.universita.corsica/fr/</ref>
          </desc>
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</tutelle>
<tutelle name="UMR6134" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
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</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1371/journal.pone.0024471</idno>
<series><title level="j">PLoS ONE</title>
<idno type="ISSN">1932-6203</idno>
<imprint><date type="datePub">2011</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en">              <p>BACKGROUND: The aim of this study was to analyse the genetic patterns of Hemagglutinin (HA) genes of influenza A strains circulating on Corsica Island during the 2006-2009 epidemic seasons and the 2009-2010 pandemic season. METHODS: Nasopharyngeal samples from 371 patients with influenza-like illness (ILI) were collected by General Practitioners (GPs) of the Sentinelles Network through a randomised selection routine. RESULTS: Phylogenetic analysis of HA revealed that A/H3N2 strains circulating on Corsica were closely related to the WHO recommended vaccine strains in each analyzed season (2006-2007 to 2008-2009). Seasonal Corsican influenza A/H1N1 isolated during the 2007-2008 season had drifted towards the A/Brisbane/59/2007 lineage, the A/H1N1 vaccine strain for the 2008-2009 season. The A/H1N1 2009 (A/H1N1pdm) strains isolated on Corsica Island were characterized by the S220T mutation specific to clade 7 isolates. It should be noted that Corsican isolates formed a separate sub-clade of clade 7 as a consequence of the presence of the fixed substitution D222E. The percentages of the perfect match vaccine efficacy, estimated by using the p(epitope) model, against influenza viruses circulating on Corsica Island varied substantially across the four seasons analyzed, and tend to be highest for A/H1N1 compared with A/H3N2 vaccines, suggesting that cross-immunity seems to be stronger for the H1 HA gene. CONCLUSION: The molecular analysis of the HA gene of influenza viruses that circulated on Corsica Island between 2006-2010 showed for each season the presence of a dominant lineage characterized by at least one fixed mutation. The A/H3N2 and A/H1N1pdm isolates were characterized by multiples fixation at antigenic sites. The fixation of specific mutations at each outbreak could be explained by the combination of a neutral phenomenon and a founder effect, favoring the presence of a dominant lineage in a closed environment such as Corsica Island.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
</list>
<tree><noCountry><name sortKey="Casabianca, Francois" sort="Casabianca, Francois" uniqKey="Casabianca F" first="François" last="Casabianca">François Casabianca</name>
</noCountry>
<country name="France"><noRegion><name sortKey="Falchi, Alessandra" sort="Falchi, Alessandra" uniqKey="Falchi A" first="Alessandra" last="Falchi">Alessandra Falchi</name>
</noRegion>
<name sortKey="Amoros, Jean Pierre" sort="Amoros, Jean Pierre" uniqKey="Amoros J" first="Jean Pierre" last="Amoros">Jean Pierre Amoros</name>
<name sortKey="Andreoletti, Laurent" sort="Andreoletti, Laurent" uniqKey="Andreoletti L" first="Laurent" last="Andreoletti">Laurent Andreoletti</name>
<name sortKey="Arena, Christophe" sort="Arena, Christophe" uniqKey="Arena C" first="Christophe" last="Arena">Christophe Arena</name>
<name sortKey="Arrighi, Jean" sort="Arrighi, Jean" uniqKey="Arrighi J" first="Jean" last="Arrighi">Jean Arrighi</name>
<name sortKey="Blanchon, Thierry" sort="Blanchon, Thierry" uniqKey="Blanchon T" first="Thierry" last="Blanchon">Thierry Blanchon</name>
<name sortKey="Flahault, Antoine" sort="Flahault, Antoine" uniqKey="Flahault A" first="Antoine" last="Flahault">Antoine Flahault</name>
<name sortKey="Hanslik, Thomas" sort="Hanslik, Thomas" uniqKey="Hanslik T" first="Thomas" last="Hanslik">Thomas Hanslik</name>
<name sortKey="Turbelin, Clement" sort="Turbelin, Clement" uniqKey="Turbelin C" first="Clément" last="Turbelin">Clément Turbelin</name>
<name sortKey="Varesi, Laurent" sort="Varesi, Laurent" uniqKey="Varesi L" first="Laurent" last="Varesi">Laurent Varesi</name>
</country>
</tree>
</affiliations>
</record>

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Genetic Structure of Human A/H1N1 and A/H3N2 Influenza Virus on Corsica Island: Phylogenetic Analysis and Vaccine Strain Match, 2006-2010.

Genetic Structure of Human A/H1N1 and A/H3N2 Influenza Virus on Corsica Island: Phylogenetic Analysis and Vaccine Strain Match, 2006-2010.

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